ADPKD History Map

46 active and 31 discontinued ADPKD programs, from first public evidence to today, by modality and stage

Timeline View

Discontinued programs run from first public evidence to last public news, active programs from first public evidence to today. Stage = furthest stage reached (discontinued) or current stage (active). Click a name for details, a reason or marker for its source.

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Legend for discontinued programs

Reason for discontinuation:EfficacySafetyStrategicNot disclosed
Line:Program activityLater news after discontinuation
Markers:MilestoneDiscontinuation announcedCorporate eventCorporate event after last ADPKD news
Active programs:First public evidence, then active to today

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200020052010201520202025StageReason ifdiscontinuedtodaySarepta · AVI-4126P1Not disclosed ↗eXegenics · PaclitaxelPCStrategic ↗Sanofi · RoscovitinePCNot disclosed ↗Octreotide-LARP3+Not disclosed ↗SirolimusP3+Efficacy ↗Novartis · EverolimusP3+Efficacy ↗Otsuka · TolvaptanAP(Active)TriptolideP2Not disclosed ↗Pfizer · BosutinibP2Not disclosed ↗LanreotideP3+Efficacy ↗Sanofi · TesevatinibP2Not disclosed ↗Biomed Valley · EtanerceptPCEfficacy ↗DiscoveryBioMed · DBM 43H11PCNot disclosed ↗Pano · PAN1021PCNot disclosed ↗Madrigal · GanetespibPCNot disclosed ↗MSDCPCNot disclosed ↗NiacinamideP2Efficacy ↗XORTX · XRx-008P1(Active)Novartis · EC0371PCNot disclosed ↗CurcuminP2Efficacy ↗ManRos · RoscovitinePCNot disclosed ↗PioglitazoneP2Not disclosed ↗Mironid · MR-L45P1(Active)Regulus · RGLS4326P1Safety ↗Lakefront · GLPG2737P2Efficacy ↗Biogen · BardoxoloneP3+Strategic ↗Vertex · VX-407P2(Active)Centessa · LixivaptanP3+Strategic ↗Sanofi · VenglustatP3+Efficacy ↗StokePCNot disclosed ↗Eloxx · ExalurenPC(Active)AsystPC(Active)Novartis · PKD researchPCNot disclosed ↗AceLink · AL01211P1Not disclosed ↗NephrogenPC(Active)Elicio · ANG-3070PCNot disclosed ↗MetforminP3+(Active)Novartis · FarabursenP1(Active)SurrozenPCNot disclosed ↗SCYNEXIS · SCY-770P1(Active)J&J · AT-20494INDNot disclosed ↗HydrochlorothiazideP3+(Active)EikonizoPC(Active)TargetSitePC(Active)AceLink · AL1311PC(Active)PYC · PYC-003P1(Active)Rege Nephro · RN-014P2(Active)RotigotineP2(Active)Alebund · AP303P2(Active)EmpagliflozinP3+(Active)HelexPC(Active)Calico · ABBV-CLS-628P2(Active)BorealisPC(Active)J&D Pharma · JD-004PC(Active)TirzepatideP2(Active)Jemincare / Jeyou · JMKX003142P2(Active)GSK · GSK4771261P1(Active)Gilva · GV-100P1(Active)Renasis BioPC(Active)Mezzion · UdenafilIND(Active)Renasant BioPC(Active)Arnatar · ART5P1(Active)Gondola BioIND(Active)AstraZeneca · AZD1613P1(Active)Mayo ClinicPC(Active)DapagliflozinP3+(Active)Bempedoic acidP2(Active)Scohia · SCO-792PC(Active)RetexPC(Active)SonoTheraPC(Active)xCystence BioPC(Active)Silver Spur · siRNAPC(Active)Torque · circRNAPC(Active)Torque · TQB-001IND(Active)Silver Spur · mRNAPC(Active)Estuary · EST-101PC(Active)Estuary · EST-201PC(Active)

Pipeline View

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Small molecule Oligonucleotide Gene therapy / editing Antibody / biologic Undisclosed Repurposing Active Possibly inactive Discontinued Click a program for details

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Modality Preclinical IND Phase 1 Phase 2 Phase 3+ Approved
mRNA-upregulating
small molecules
mRNA-upregulating
ASOs
PKD protein
correctors
Signaling
modulators
Read-through
correctors
Gene therapy
Gene editing
Antibody /
biologic
Undisclosed
Repurposing